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Sirano Dhe Paganon, PhD - Structural & Chemical Biology Center

Structural & Chemical Biology Center
SIRANO DHE-PAGANON, PHD

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HIT-VALIDATION OVERVIEW

Validate and map the precise mechanism of action of your hits or tool compounds with results from biophysical characterization and crystallography. In our lab, proteins are expressed and purified to milligram quantities for the following analyses:
  • ITC: Isothermal Titration Calorimetry, automated and high-throughput; Register for the EnthalpyScreen webinar!
  • DSF: Differential Scanning Fluorimetry or Thermal Stabilization
  • FP: Fluorescence Polarization
  • Activity: Catalytic activity assay measurements
  • Crystallography:  High resolution crystal structures


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